Olinkは、わずか1µLのサンプルから一度に多量検体の測定を可能とします。そのため、脳脊髄液、細胞外小胞、小児検体などの、バイオマーカーとしての可能性を秘めた希少サンプルの分析を実現します。
ここでは、希少サンプルに対してInflammation パネルを用いて分析した論文を紹介いたします。
脳脊髄液
変形性関節症、神経炎症
Palada V, Siddiqah Ahmed A, Freyhult E, et al. Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity. (2020) Journal of Neuroimmunology,
DOI: 10.1016/j.jneuroim.2020.577391
© 2020 The Authors.
感染症(HIV)、神経炎症
Duran-Castells C, Llano A, Kawana-Tachikawa A, et al. Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1Infection and HIV-Related Neurological Dysfunction. (2023) Journal of Virology,
DOI: 10.1128/jvi.01655-22
© 2023 Duran-Castells et al.
関節液
リウマチ、乾癬性関節炎
Barbarroja N, López-Montilla M, Cuesta-López L, et al. Characterization of the inflammatory proteome of synovial fluid from patients with psoriatic arthritis: Potential treatment targets. (2023) Frontiers in Immunology,
DOI:10.3389/fimmu.2023.1133435
© 2023 Barbarroja, López-Montilla, Cuesta-López, Pérez-Sánchez, Ruiz-Ponce, López-Medina, Ladehesa-Pineda, López-Pedrera, Escudero-Contreras, Collantes-Estévez and Arias-de la Rosa.
変形性関節症
Aulin C, Larsson S, Vogl T, et al. The alarmins high mobility group box protein1 and S100A8/A9 display different inflammatory profiles after acute knee injury. (2022) Osteoarthritis and Cartilage,
DOI: 10.1016/j.joca.2022.06.009
© 2022 The Author(s).
細胞外小胞
2型糖尿病、動脈硬化
Palada V, Siddiqah Ahmed A, Freyhult E, et al. Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity. (2020) Journal of Neuroimmunology,
DOI: 10.1016/j.jneuroim.2020.577391
© The Author(s) 2020.
乾燥血液スポット
小児、血小板輸血
Moore CM, O’Reilly D, McCallion N, et al. Changes in inflammatory proteins following platelet transfusion in a neonatal population. (2023) Pediatric Research,
DOI: 10.1038/s41390-023-02731-x
© The Author(s) 2023.
小児検体
自己免疫疾患、肝炎
Sîrbe C, Badii M, Crişan T, et al. Detection of Novel Biomarkers in Pediatric Autoimmune Hepatitis by Proteomic Profiling. (2023) International Journal of Molecular Sciences,
DOI: 10.3390/ijms24087479
© 2023 by the authors.
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