Olink Target 48 Cytokine は、わずか 1μL の血清・血漿サンプルから一度に 45因子 のサイトカイン類を絶対定量します。
ここでは、さまざまな研究分野において、 Olink Target 48 Cytokine が活用されている事例を紹介いたします。
免疫学/炎症学
口腔、炎症、バイオマーカー
Virdee SS, Bashir N, Krstic M, et al. Periradicular tissue fluid-derived biomarkers for apical periodontitis: an in vitro methodological and in vivo cross-sectional study. (2023) International Endodontic Journal,
DOI: 10.1111/iej.13956
© 2023 The Authors.
食道、炎症
Kleuskens MTA, Bek MK, Al Halabi Y, et al. Mast cells disrupt the function of the esophageal epithelial barrier. (2023) Mucosal immunology,
DOI: 10.1016/j.mucimm.2023.06.001
© 2023 The Author(s).
腸管、遺伝子変異
Rodari MM, Cazals-Hatem D, Uzzan M, et al. Insights into the expanding intestinal phenotypic spectrum of SOCS1 haploinsufficiency and therapeutic options. (2023) Journal of Clinical Immunology,
DOI: 10.1007/s10875-023-01495-7
© 2023. The Author(s).
喘息、感染
Radzikowska U, Eljaszewicz A, Tan G, et al. Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19. (2023) Nature Communications,
DOI: 10.1038/s41467-023-37470-4
© 2023. The Author(s).
薬理学、グルココルチコイド
Othonos N, Pofi R, Arvaniti A, et al. 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial. (2023) Nature Communications,
DOI: 10.1038/s41467-023-36541-w
© 2023. The Author(s).
神経学
スポーツ関連脳震盪、免疫
Di Battista AP, Rhind SG, Shiu M, et al. Whole blood stimulation provides preliminary evidence of altered immune function following SRC. (2024) BMC Immunology,
DOI: 10.1186/s12865-023-00595-8
© Crown 2024.
アルツハイマー、臨床試験
Faridar A, Eid AM, Thome AD, et al. A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease. (2023) Translational Neurodegeneration,
DOI: 10.1186/s40035-023-00387-5
© 2023. The Author(s).
多発性硬化症、免疫吸着療法
Pfeuffer S, Rolfes L, Wirth T, et al. Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses. (2022) Journal of Neuroinflammation,
DOI: 10.1186/s12974-022-02583-y
© 2022. The Author(s).
老化
高齢者、骨粗鬆症、骨折、バイオマーカー
Cedeno-Veloz BA, Lozano-Vicario L, Zambom-Ferraresi F, et al. Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults. (2023) Immunity & Ageing,
DOI: 10.1186/s12979-023-00379-z
© The Author(s) 2023.
栄養学
栄養、免疫
Kawano T, Miura A, Naito J, et al. High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study. (2023) Journal of Functional Foods,
DOI: 10.1016/j.jff.2023.105804
© 2023 The Authors.
感染症(COVID-19)
COVID-19後遺症、マルチオミクス
Mahdi A, Zhao A, Fredengren E, et al. Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study. (2023) Scientific Reports,
DOI: 10.1038/s41598-023-47539-1
© The Author(s) 2023
COVID-19、バイオマーカー
Rosendal E, Mihai IS, Becker M, et al. Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections. (2022) mBio,
DOI: 10.1128/mbio.00892-22
© 2022 Rosendal et al.
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