Olinkは、わずか１µLのサンプルから一度に多量検体の測定を可能とします。そのため、脳脊髄液、細胞外小胞、小児検体などの、バイオマーカーとしての可能性を秘めた希少サンプルの分析を実現します。
ここでは、希少サンプルに対してInflammation パネルを用いて分析した論文を紹介いたします。
脳脊髄液
自己免疫疾患、神経炎症
Stevens-Jones O, Mojzisova H, Elisak M, et al. Paraneoplastic or not?Sirtuin-2 in anti-N-methyl-D-aspartate receptor encephalitis. (2023)European Journal of Neurology,
DOI: 10.1111/ene.15987
感染症（結核）、神経炎症
Koeken V, Ganiem A, Dian S, et al. Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality. (2020)Tuberculosis,
DOI: 10.1016/j.tube.2020.10201
変形性関節症、神経炎症
Palada V, Siddiqah Ahmed A, Freyhult E, et al. Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity. (2020) Journal of Neuroimmunology,
DOI: 10.1016/j.jneuroim.2020.577391
感染症（HIV）、神経炎症
Duran-Castells C, Llano A, Kawana-Tachikawa A, et al. Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1Infection and HIV-Related Neurological Dysfunction. (2023) Journal of Virology,
DOI: 10.1128/jvi.01655-22
COVID-19、神経障害
Remsik J, Wilcox J, Babady NE, et al. Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients. (2021) Cancer Cell,
DOI: 10.1016/j.ccell.2021.01.007
細胞外小胞
動脈硬化
Maaninka K, Neuvonen M, Kerkelä E, et al. OxLDL sensitizes platelets for increased formation of extracellular vesicles capable of finetuning macrophage gene expression. (2023) European Journal of Cell Biology, DOI:10.1016/j.ejcb.2023.151311
臓器移植、拒絶反応
Celik S, Sadrian J, Grossi M, et al. Extracellular Vesicle-Associated TWEAK Contributes to Vascular Inflammation and Remodeling During Acute Cellular Rejection. (2023) JACC: Basic to Translational Science,
DOI: 10.1016/j.jacbts.2022.09.014
2型糖尿病、動脈硬化
Palada V, Siddiqah Ahmed A, Freyhult E, et al. Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity. (2020) Journal of Neuroimmunology,
DOI: 10.1016/j.jneuroim.2020.577391
気管支肺胞洗浄液
COVID-19、間質性肺炎、神経炎症
Verma A, Hawes CE, Lakshmanappa YS, Roh JW, et al. Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation. (2021) Cell Reports,
DOI: 10.1016/j.celrep.2021.109942
関節液
リウマチ、乾癬性関節炎
Barbarroja N, López-Montilla M, Cuesta-López L, et al. Characterization of the inflammatory proteome of synovial fluid from patients with psoriatic arthritis: Potential treatment targets. (2023) Frontiers in Immunology, DOI:10.3389/fimmu.2023.1133435
変形性関節症
Aulin C, Larsson S, Vogl T, et al. The alarmins high mobility group box protein1 and S100A8/A9 display different inflammatory profiles after acute knee injury. (2022) Osteoarthritis and Cartilage,
DOI: 10.1016/j.joca.2022.06.009
動脈血・冠動脈洞血
心不全
Kaye D, Nanayakkara S, Wang B, et al. Characterization of Cardiac Sympathetic Nervous System and Inflammatory Activation in HFpEF Patients.(2022) JACC: Basic to Translational Science,
DOI: 10.1016/j.jacbts.2021.11.007
皮膚生検
乾癬、化膿性乾癬炎
Navrazhina K, Garcet S, Frew JW, et al. The inflammatory proteome of hidradenitis suppurativa skin is more expansive than that of psoriasis vulgaris.(2021) Journal of the American Academy of Dermatology,
DOI: 10.1016/j.jaad.2021.07.035
乾燥血液スポット
小児、血小板輸血
Moore CM, O’Reilly D, McCallion N, et al. Changes in inflammatory proteins following platelet transfusion in a neonatal population. (2023) Pediatric Research,
DOI: 10.1038/s41390-023-02731-x
小児検体
自己免疫疾患、肝炎
Sîrbe C, Badii M, Crişan T, et al. Detection of Novel Biomarkers in Pediatric Autoimmune Hepatitis by Proteomic Profiling. (2023) International Journal of Molecular Sciences,
DOI: 10.3390/ijms24087479
炎症性腸疾患
Nyström N, Prast-Nielsen S, Correia M, et al. Mucosal and plasma metabolomes in new-onset paediatric inflammatory bowel disease:correlations with disease characteristics and plasma inflammation protein markers. (2022) Journal of Crohn’s & Colitis,
DOI: 10.1093/ecco-jcc/jjac149
肥満
Stinson SE, Jonsson AE, Andersen MK, et al. High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity. (2023) Journal of the American Heart Association,
DOI: 10.1161/JAHA.122.027042
炎症性腸疾患
Ungaro R, Hu L, Ji J, et al. Machine learning identifies novel blood protein predictors of penetrating and stricturing complications in newly diagnosed paediatric Crohn’s disease. (2020) Alimentary Pharmacology & Therapy, DOI:10.1111/apt.16136
炎症性腸疾患
Jongsma MME, Costes LMM, Tindemans I, et al. Serum immune profiling in pediatric Crohn’s disease demonstrates stronger immune modulation with first-line infliximab than conventional therapy and pre-treatment profiles predict clinical response to both treatments. (2023) Journal of Crohn’s &Colitis,
DOI: 10.1093/ecco-jcc/jjad049